AMYLIN RECEPTOR ANTAGONISTS

AMYLIN RECEPTOR ANTAGONISTS inhibit the actions of agonists at receptors recognizing amylin. There are no selective agents; however, an analogue of calcitonin, AC 187 (acetyl-[Asn30,Tyr32]-salmoncalcitonin832) acts mainly as an amylin receptor antagonist and inhibits several metabolic actions of amylin. Amylin837 also acts as an antagonist.