Clinical Uses Feverfew is used to prevent and treat migraine headaches. Historical Uses Traditionally, feverfew was used to manage labor pains, to reduce fevers, and to repel insects. Growth Feverfew is a member of the daisy family and may be grown in herb gardens in the spring. The plant prefers dry soil and sun. Feverfew: Part Used • Leaves Major Chemical Compounds • Sesquiterpene lactones, primarily parthenolide Feverfew: Clinical Uses Feverfew is used to prevent migraine headaches and also to treat migraine headaches. Mechanism of Action The mechanism by which feverfew works is not fully understood. It may act like non-steroidal anti-inflammatory drugs (NSAIDs) by interfering with the first step of thromboxane synthesis (inhibiting prostaglandin biosynthesis), but it differs from salicylates in that it does not inhibit cyclo-oxygenation by prostaglandin synthase. Feverfew inhibits serotonin release from platelets and polymor-phonuclear leukocyte granules, which benefits patients with migraines or arthritis (The Lawrence Review of Natural Products, 1994). It has shown antinociceptive and anti-inflammatory effects in animals. Feverfew: Dosage To be effective at preventing migraines, the parthenolide Read more […]
Archive for category Feverfew'
Tanacetum parthenium Sch.Bip. (Asteraceae) Synonym(s) and related species Altamisa, Featherfew, Featherfoil, Midsummer daisy. Chrysanthemum parthenium (L.) Bernh., Leucanthemum parthenium (L.) Gren & Godron, Pyrethrum parthenium (L.) Sm. Pharmacopoeias Feverfew (British Ph 2009, European Ph 2008, US Ph 32); Powdered Feverfew (The United States Ph 32). Constituents The leaf and aerial parts contain sesquiterpene lactones, especially parthenolide, its esters and other derivatives, santamarin, reynosin, artemorin, partholide, chrysanthemonin and others. The volatile oil is composed mainly of alpha-pinene, bornyl acetate, bornyl angelate, costic acid, camphor and spirotekal ethers. Use and indications Feverfew is mainly used for the prophylactic treatment of migraine and tension headache, but it has antiplatelet and anti-inflammatory activity, and has been used for coughs, colds and rheumatic conditions. It can cause allergic and cytotoxic reactions due to the presence of sesquiterpene lactones with an alpha-methylene butyrolactone ring, as in parthenolide. Pharmacokinetics In a study investigating the in vitro inhibitory potency of an extract of feverfew using a commercially available mixture of cytochrome Read more […]
Toxicity Unknown, although no major safety issues have been identified. Adverse Reactions According to a Cochrane systematic review of five studies, feverfew is well tolerated and adverse events are generally mild and reversible. Symptoms were most frequently reported by long-term users and were predominantly mouth ulceration and gastrointestinal symptoms. Contact dermatitis, mouth soreness and lip swelling has also been reported when leaves are chewed. Significant Interactions Controlled studies are not available; therefore, interactions are based on evidence of activity and are largely theoretical and speculative. ANTICOAGULANTS Theoretically, feverfew may increase bruising and bleeding; however, although feverfew inhibits platelet aggregation in vitro and in vivo, no effects were seen in a clinical study — observe patients taking this combination. ANTIPLATELET DRUGS Theoretically, feverfew may increase bruising and bleeding; however, contradictory evidence exists — observe patients taking this combination. Contraindications and Precautions Hypersensitivity to plants in theAsteraceae (Compositae) (daisy) family (e.g. chamomile, ragweed). Pregnancy Use Contraindicated in pregnancy. Practice Points Read more […]
Clinical Use PROPHYLAXIS OF MIGRAINE HEADACHE The first double-blind study investigating feverfew in migraine prophylaxis was published in 1985 and involved 17 patients who had been chewing fresh feverfew leaves on a daily basis. Therapeutic effect was maintained when capsules containing freeze-dried feverfew powder were continued, whereas those allocated placebo capsules experienced a significant increase in the frequency and severity of headache, nausea, and vomiting during the early months of withdrawal. Since then, numerous clinical studies have been conducted to determine the role of feverfew in the prevention of migraine headache. In 2000, Ernst and Pittler published a systematic review of six randomised, placebo-controlled double-blind trials of feverfew as a prophylactic treatment and concluded that the current evidence favours feverfew as an effective preventative treatment against migraine headache, and is generally well tolerated. Clinical note — Migraine Migraine is a common episodic familial headache disorder characterised by a combination of headache and neurologic, gastrointestinal, and autonomic symptoms. It has a 1 -year prevalence of approximately 18 % in women, 6% in men, and 4% in children Read more […]
Historical Note Feverfew has been used for centuries in Europe to treat headaches, arthritis and fever and used as an emmenagogue and anthelmintic agent. In the 1970s it was ‘rediscovered’ by the medical establishment and subjected to clinical studies, which produced encouraging results that suggested feverfew was an effective prophylactic medicine for migraine headache. Other Names Altamisa, bachelor’s button, camomile grande, featherfew, featherfoil, chrysanthemum parthenium, mutterkraut, matrem, tanaceti parthenii herba/folium Botanical Name / Family Tanacetum parthenium (family [Asteraceae] Compositae) Plant Part Used Leaf Chemical Components The leaves and flowering tops contain many monoterpenes and sesquiterpenes as well as sesquiterpenes lactones (chrysanthemolide, chrysanthemonin, 10-epi-canin, magnoliolide and parthenolide), reynosin, santamarin, tanaparthins and other compounds. Until recently, the sesquiterpene lactone parthenolidewas thought to be the major biologically active constituent. However, in vitro and in vivo research suggests others are also present. Clinical note – Natural variations in parthenolide content The amount of parthenolide present in commercial preparations of feverfew Read more […]