Archive for category Melilot'

Herb-Drug Interactions: Melilot

Melilotus offidnalis (L.) Pall. (Fabaceae) Synonym(s) and related species King’s clover, Sweet clover, Ribbed melilot, Yellow melilot, Yellow sweet clover. Melilotus arvensis Wallr. Pharmacopoeias Melilot (British Ph 2009, European Ph, 6th ed., 2008 and Supplements 6.1, 6.2, 6.3 and 6.4). Constituents The main active constituents of melilot are natural coumarin and its derivatives, melilotin, melilotol, dihydrocoumarin, umbelliferone and scopoletin, which are formed on drying from the glycoside melilotoside. If spoilage and subsequent fermentation occur, some coumarin derivatives can be transformed into the potent anticoagulant dicoumarol (bishydroxycoumarin). Other constituents present are flavo-noids (including quercetin) and a number of saponins. Use and indications Melilot is used mainly to treat inflammation, oedema and capillary fragility. Pharmacokinetics No relevant pharmacokinetic data for melilot found. For information on the pharmacokinetics of individual flavo-noids present in melilot, see under flavonoids. Interactions overview Two cases describe bleeding and a raised INR in patients taking a tea and using a topical cream containing melilot, but an interaction has not been established. Read more […]