Archive for category Natural coumarins'

Herb-Drug Interactions: Natural coumarins

Natural coumarins are widespread in herbal medicines and vegetables. There is a misconception that if a plant contains natural coumarins it will have anticoagulant properties, but very specific structural requirements are necessary for this – namely there must be a non-polar carbon substituent at the 3-position of 4-hydroxycoumarin. Moreover, at present, there are no established interactions between warfarin and herbal medicines that have been attributed to the natural coumarin content of the herb. Even in the classic case of haemorrhagic death of livestock that led to the discovery of dicoumarol, it was the action of the mould on the natural coumarin in the sweet clover (melilot) that led to the production of the anticoagulant, so consumption of a spoiled product would seem to be necessary for this specific interaction to occur. This suggests that the occurrence of natural coumarins in dietary supplements or herbal medicines should not trigger immediate concern as regards interactions with anticoagulants. The information in this family monograph relates to the individual natural coumarins, and the reader is referred back to the herb (and vice versa) where appropriate. Note that, to avoid confusion with the synthetic Read more [...]