Archive for category Perilla'

Perilla and the Treatment of Allergy

Perilla (Perilla frutescens Britt.), a traditional Chinese herb, has recently received special attention because of its beneficial effects in the treatment of some kinds of allergic reactions without the side effects associated with some other used antiallergy medicines. In this chapter, the authors present a review of the problem of allergy and the current favorable evidence for the use of Perilla products towards its resolution. The Allergy Problem Allergy is an abnormal immune reaction of the body to allergens such as pollen, dust, certain foods, drugs, animal fur, animal pets, animal excretions, feathers, microorganisms, cosmetics, textiles, dyes, smoke, chemical pollutants and insect stings. Certain conditions such as cold, heat, or light may also cause allergic symptoms in some susceptible people. Some allergens are just specific to some individuals but not to others. Allergens may act via inhalation, ingestion, injection or by contact with the skin. The resulting allergy may cause the victim to have a medical problem such as hay fever (allergicrhinitis), or atopic dermatitis (eczema), or allergic asthma, with symptoms ranging from sneezing, rhinorrhea, nasal itch, obstruction to nasal air-flow, loss of sense Read more […]

Application of Perilla Leaf Extract for Allergy

In addition to the factory made Perilla products, several other methods for Perilla preparation are available in the folklore of China and Japan (). The application of home made Perilla extract is also used for the treatment of allergy. However, the removal from the extract of agricultural chemicals and perillaldehyde, which might be allergens to some individuals is important (). Administration of Perilla Leaf Extract Dr. Oyanagi et al. reported their experiences in treating allergy patients with Perilla products (). According to the different symptoms and the condition of the patients administration may be singly or combined (). Oral administration For the concentrated products of Perilla extract, the dose was 0.3-2 ml/50—100 ml water or other drink, 2-3 times daily dependent on the age. With home made or diluted extract, the dosage varied with the concentration and methods of preparation. Nasal application To relieve the symptoms of an itching or running nose, the Perilla extract was applied inside the nostrils using a cotton bud. Topical application of Perilla extract Application to the skin was helpful in relieving the itching and redness. Topical use of Perilla cream and soap For some atopic dermatitis, Read more […]

The Possible Mechanisms of Perilla in the Treatment of Allergy

Although the precise mechanisms of Perilla treatment for allergy are not yet well elucidated, recent researches on the various phytochemicals and their pharmacological properties have also revealed some mechanisms of Perilla action in allergy. Kosuna () recently published a review on anti-inflammatory active compounds in Perilla. Several active components contained in Perilla have been found to be linked with antiallergy and anti-inflammatory actions. These include elemicine, CX-pinene, caryophyllene, myristicin, β-sitosterol, apigenin, phenylpropanoids and also some flavonoids which act as anti-inflammatory agents (). From current knowledge, the mechanisms of allergy treatment by Perilla may involve the following aspects which are Linked to the regulation of the condition by the immune system. Perilla Leaf Extract TNF inhibition Relevant to this section is the Perilla leaf extract which contains active components of molecular weight less than 10000. As mentioned above, Yamazaki reported that Perilla extract was shown to be active in inhibiting TNF production (). Kosuna proposed that more than ten active components contained in the Perilla leaf extract were active in inhibiting TNF production which plays an important Read more […]

Applications and Prescriptions of Perilla in Traditional Chinese Medicine

Since the advent of “Shen Nong Ben Cao Jing” (Shen Nong’s Herbal), the progenitor of herbals in traditional Chinese medicine, completed around 25 A.D., which classified herbal drugs into upper grade, mid-grade and lower grade, all subsequent herbals classified Chinese herbal drugs according to this tradition. The upper grade drugs are known as the imperial drugs which are non-poisonous and arc used mainly for nurturing our lives; the mid-grade drugs are known as the ministerial drugs which are either non-poisonous or poisonous and are used chiefly to nurture our temperament; and the lower grade drugs are known as the assistant or servant drugs which are used for treating disease and are mostly poisonous. In clinical diagnosis, a physician of traditional Chinese medicine will first consider the circulation of qi, blood and water. The so-called blood conformation in traditional Chinese medicine (a conformation in traditional Chinese medicine can be approximated to a symptom complex or syndrome in Western medicine) refers to “blood stasis” which is a poor blood circulation condition resulted from congestion or stagnation of blood in the body and may lead to formation of disease. A water conformation is also referred Read more […]

Commonly used chinese herb formulas that contain Perilla

As mentioned above, Perilla is often used together with other Chinese herbs in many herb formulas, especially in the qi formulas used for treating neurotic disorders, and respiratory diseases. In addition, it is also commonly used as a diaphoretic for common cold. Some commonly used Chinese herb formulas that contain Perilla leaf are shown in Tables Commonly used traditional Chinese herb formulas that contain Perilla leaf and Chinese herb formulas that contain Perilla leaf as recorded in the pharmacopoeia of PRC. And some commonly used Chinese herb formulas containing Perilla seed or fruit are shown in Table Commonly used traditional Chinese herb formulas that contain Perilla seed. Table Commonly used traditional Chinese herb formulas that contain Perilla leaf Formula Source Number of Herbs Content (%) of   Perilla Leaf Pinellia and Magnolia Combination Jin-gui-yao-lue 5 10.0 Ephedra and Magnolia Combination Wai-tai-mi-yao 7 7.5 Cyperus and Perilla Formula Tai-ping-hui-min-he-ji-ju-fang 5 15.0 Ginseng and Perilla Combination Tai-ping-hui-min-he-ji-ju-fang 13 4.4 Dang-guei Sixteen Herbs Combination Wan-bing-hui-chun 16 5.3 Aquilaria and Perilla Formula Tai-ping-hui-min-he-ji-ju-fang 11 9.8 Citrus Read more […]

A Clinical Investigation of Perilla Extract Cream for Atopic Dermatitis

Atopic dermatitis is one kind of allergic disease. Allergies are very closely associated with an immune response. When the human body is invaded by a foreign substance (antigen), antibodies or sensitised lymphocytes will be produced as a result of the response of the immune system. Later when the same antigen invades the body again, it will soon be eliminated or become harmless to the body. This is an immune response which is an indispensable function to prevent infection and tumours. However, sometimes the immune reaction between antigen and antibodies or sensitised lymphocytes can cause harm to the body itself. This kind of immune reaction in which antigen comes from outside the body causes allergic disease, whereas antigen which comes from the body itself causes auto-immune disease. According to the statistical investigation in 1992 by the Ministry of Welfare of Japan, 34% of the Japanese population suffer from some kind of allergy, and most of them are children between the age of 0 to 4. There is the tendency for allergic symptoms to appeal- as atopic dermatitis in childhood and to become asthma or rhinitis as they mature. The word atopy is derived from Greek () and means odd and thus atopic dermatitis is Read more […]

Perilla: Practice Points – Patient Counselling. FAQ

Perilla exhibits anti-inflammatory, anti-allergic, antioxidant and anticariogenic activity. Preliminary evidence also suggests hepatoprotective and behavioural effects. • Perilla leaf and defatted seed extracts are specifically used for allergic respiratory disorders including hay fever, asthma and sinusitis. • Perilla leaf and defatted seed extract may downregulate Th2-type cytokine production and prevent theTh1/Th2 balance from shifting toward Th2-type immune responses that may be associated with a range of allergic reactions and autoimmune disorders. • Perilla refined oil is a good source of n-3 series alpha-linolenic acid and extracts should be free of perillyl ketones and aldehydes. Answers to Patients’ Frequently Asked Questions What can this herb do for me? Perilla is used in the treatment of allergic respiratory conditions, such as hay fever, asthma and sinusitis. Preliminary evidence suggests that it may be beneficial; however, more rigorous studies are still required to confirm effectiveness. When will it start to work? Relief of symptoms should be noticed within the first week, although it may take a couple of weeks to show a significant effect. For hay fever, it would be Read more […]

Perilla: Significant Interactions. Contraindications and Precautions. Pregnancy Use

Adverse Reactions Perilla defatted seed extract has very low toxicity. After administering 2000 mg/kg to mice for 2 weeks, no toxic effects were observed (LD50 for mice is therefore more than 2000 mg/kg). Dosage of 7.0 g/kg for 2 weeks did not produce any toxic effects in humans. In Japan, 20-50% of long-term workers in the perilla industry develop dermatitis on their hands due to contact with perillyl aldehyde. A 13-week subchronic oral toxicity study of perilla leaf extracts in drinking water did not show any acute toxicity. There were no treatment-related changes in body weight gain or in haematological or blood biochemistry values. Nor were there any treatment-related histopathological changes observed in the highest dose group. There has been a report of lipoid pneumonia in a 57-year-old man who had a history of ingesting green perilla oil, and there was also residual neurologic deficit of cerebral infarction with right hemiparesis. Phase I and II clinical trials of perillyl alcohol for certain cancers have shown that gastrointestinal side-effects and fatigue are the most common adverse reactions. Gastrointestinal effects are usually mild and include nausea, vomiting, bloating and belching. Doses were Read more […]

Perilla: Clinical Use. Dosage

The form most commonly used at the moment is the perilla seed defatted extract; however, this review will also include information regarding other forms. CANCER Phase I clinical trials have shown a favourable toxicity profile and preliminary data have indicated somechemotherapeutic efficacy in advanced cancers. However, perillyl alcohol (1200 mg/m2 four times daily) failed to extend the time-to-progression in three phase II studies in patients with advanced ovarian carcinoma, prostate cancer and colorectal cancer. All trials were very small and had to contend with high drop-out rates due to intolerabihty of the medicine. Despite encouraging preclinical results, perilla does not appear to be an effective treatment for advanced cancer. ALLERGY Based on traditional use, in vitro and in vivo studies, and human trials, perilla leaf and defatted seed extracts are used for allergic respiratory disorders including hay fever, asthma and sinusitis. The refined oil may also help allergic and inflammatory respiratory conditions by regulating the arachidonic acid metabolism pathways. A double-blind, randomised, placebo-controlled clinical trial showed a significant reduction in symptoms such as watery eyes, itchy eyes and Read more […]

Perilla: Background. Actions

Common Name Perilla Other Names Beefsteak plant, Chinese basil, Purple perilla, wild sesame (English common names), Ban Tulsi (Bengali), Su Zi (Mandarin), Shosi, Egoma (Japanese). Different names are used for the different parts of the perilla plant used as foods or medicines. Botanical Name / Family Perilla frutescens (L.) Britt. There are several botanical variants that seem to be used interchangeably: P. frutescens var. crispa, P. frutescens var. japonica (family Lamiaceae or Labiatae [mint family]). Plant Parts Used Leaf, stem and the fruit (seed) are used. Historical Note Perilla is an annual plant native to Eastern Asia. It was introduced to Japan from China and is now cultivated extensively in Japan, India and Korea. The seed is mainly used for its high oil content, and the leaves of Perilla frutescens var. crispa are used as a vegetable and food colouring. The salty umeboshi plum is coloured by the addition of special red perilla leaves. In China perilla has been used to reduce the risk of food poisoning by cooking seafood with the leaf. In recent times, certain compounds (monoterpines) isolated from the oil are being investigated as an anticancer treatment, and the defatted seed extract is used Read more […]