Catha edulis (Khat)

2015

Distribution, Botany, and Morphology

Khat, Catha edulis (Vahl) Forssk. ex Endl. (Celasteraceae), is an evergreen shrub or tall tree that may reach up to 25 m in height if not pruned. Extensive pruning makes it a small shrub, as it is usually described. Its life span may extend for 40 years. The plant is indigenous to East Africa and southern Arabia, but may have originated in the Harar district of Ethiopia, according to earlier reports. Its habitat extends from northern Ethiopia to the mountainous regions of East Africa and Yemen, all the way to south Africa, between latitudes 18 °N and 30 °S. It is cultivated mostly on hillsides and mountain slopes at altitudes of 1500-2000 m above sea level. Besides Ethiopia and Yemen, the khat plant is now grown in Djibouti, Somalia, Kenya, Tanzania, Uganda, and Madagascar. However, the use of the plant is by no means restricted to the natives of these countries, but extends to other Asian countries and immigrant communities in several Western countries.

The fact that the khat plant is not allowed to produce seeds and is mainly propagated by cuttings, and that only fresh leaves are used, may have confined its cultivation to the regions of origin and neighboring areas. In these regions, khat is known by different names, e.g., chat, tschat, qat or gat, Mirraa, murraa, etc. depending on the language of the region (United Nations 1978).

Both earlier and more recent investigations on khat revealed similar observations on the important morphological features that may assist in the identification of khat from various geographical origins. The leaves may vary in shape, size, and color according to degree of development and botanical origin. They are simple, oval-lanceolate in shape with acute apex and base, and are serrated along the entire margin except for a portion of the lower base. They are opposite or alternate in arrangement, and measure 4-11 cm long and 1.8-5 cm wide at the widest part. The youngest leaves are tender, thin, glossy, brownish green in color while the older ones are bright green, fibrous with clear pinnate venation, and sometimes with red rust-like spots. The leaves are odorless and have an astringent taste.

Nordal described the flower of khat as the smallest within the dicotyledons. The flower is hermaphrodite, carried on a short peduncle, and consists of five sepals, five yellowish white petals, and five stamens. The fruit has an average length of 8-10 mm and a diameter of 2-3 mm. The fruit has three or four carpels and is six-to eight-loculate, but only two or three small, brown seeds develop in the fruit.

The Khat Habit

The habit of chewing khat leaves is a deeply rooted and widely accepted social tradition among the inhabitants of Yemen and Ethiopia. This is particularly dealt with in a comprehensive review by Krikorian. The chewing is commonly practiced in groups. The participants gather daily or frequently during the week for 2 to 4h, in what may be called a khat party or session. Both men and women chew in separate or mixed groups, depending on the culture of the region.

Khat is sold in bundles of fresh branches (30-40 branches/bundle) which are carefully wrapped in green banana leaves to preserve their freshness. The youngest leaves and tender twigs are stripped off the branch and chewed. The juice is swallowed with the saliva and the residue of the leaf material is stored in the mouth, forming a bulge in one cheek for the whole period of chewing. Cold soft drinks are usually taken to nullify the feeling of thirst normally experienced during chewing.

On the average, each person consumes 100-200 g of fresh leaves, i.e., one bundle in one session. At the end of the session, the stored material is ejected.

Effects of Khat

Ever since khat was known it has been said to alleviate hunger and fatigue. This has recently been explained on the basis of its stimulation of the central nervous system (CNS). As a result, the consumer of khat experiences a state of euphoria, mental alertness, and excitement. Many khat users admit an increased intellectual ability, enhanced depth of perception, and feelings of grandiosity. These effects are felt during the session, which may be prolonged as a result. After the session the characteristic effects are anorexia, insomnia, depression, gastritis, and constipation (WHO 1980). The latter effects could be due to the high tannin content of khat leaves, which are known to interfere with the absorption of proteins, and are also increasingly implicated in esophageal cancer. Beside its reinforcing effects, khat is said to be a folk remedy for asthma, bronchial disorders, flu, cough, and lethargy.

It has been claimed that khat increases sexual desire (libido), but may also inhibit the performance and be inhibitory as well. Long-term habitual use may lead to impotence and spermatorrhea. Also, khat extracts have been shown to increase sperm abnormalities in male rats, decrease sperm count and motility, and reduce female fertility in mice and rats.

Earlier, an expert group of the World Health Organization (WHO 1964) found the effects of khat to be similar to those of amphetamine, and that long-term habitual use of khat may lead to psychic dependence. Indeed, this behavior is manifested by many khat users, who seek to secure their khat supplies by any means at the expense of other vital needs. Accordingly, khat was included in the list of psychotropic substances (WHO 1985). It is noteworthy that withdrawal after prolonged use produces only minor symptoms such as mild depression, and increased desire to sleep, sometimes accompanied with delusions and hallucination. The habitual use of khat may therefore lead to serious problems of social, health, and economic nature.

Summary and Conclusions

In view of the widespread use of khat, and the occurrence of ecotypes or chemotypes that vary considerably with respect to alkaloidal content and presumably in potency, as indicated by consumer preferences for certain types of khat, it is essential to provide researchers with fresh and uniform plant material when needed. In this respect, clonal propagation has been achieved via three distinct stages. Stage I for multiple bud formation required a higher BA/IAA ratio; stage II for shoot development and elongation needed a lower BA/IAA ratio, stage III for rooting required IAA only, followed by hardening and transfer to soil.

In contrast to micropropagation, callus induction proved to be a slow process, requiring the provision of PVP to reduce the browing effect, in a medium containing NAA or IBA (3 mg).

The detection of cathinone in leaf tissues of micropropagated plantlets and its absence in undifferentiated callus tissues suggest that cathinone synthesis is related to morphological development. The formation of phenolic compounds by callus tissues is interesting.

Selections from the book: “Medicinal and Aromatic Plants IX” (1996).