Herb-Drug Interactions: Chondroitin

Types, sources and related compounds

Chondroitin sulfate sodium.


Chondroitin sulphate sodium (British Ph 2009, Ph. Eur. 6.4); Chondroitin sulfate sodium (The United States Ph 32).

Use and indications

Chondroitin is an acid mucopolysaccharide and is found naturally in cartilage and connective tissue. Supplemental chondroitin is used for the management of arthritis and is often given with glucosamine, for osteoarthritis.


Chondroitin is rapidly adsorbed from the gastrointestinal tract and the absolute bioavailability of an oral dose is about 15%. It is distributed into numerous tissues, with a particular affinity to articular cartilage and synovial fluid.

Interactions overview

No interactions with chondroitin taken alone found, but chondroitin is often given with glucosamine. For information on these interactions, see under glucosamine.