Herb-Drug Interactions: Gotu kola

2011

Centella asiatica (L.) Urb. (Apiaceae)

Synonym(s) and related species

Asiatic pennywort, Centella, Gota kola, Gotu cola, Hydrocotyle, Indian pennywort, Indian water navelwort. Hydrocotyle asiatica L., Hydrocotyle lurida Hance.

Pharmacopoeias

Centella (British Ph 2009, European Ph, 6th ed., 2008 and Supplements 6.1, 6.2, 6.3 and 6.4).

Constituents

Gotu kola contains a wide range of triterpene saponin glycosides such as asiaticoside (to which it may be standardised), centelloside, madecassoside, brahmoside, brahminoside and others. Free asiatic, centellic, centoic betulinic and madecassic acids are also present and these are considered to be the main active constituents. Flavonoids based on quercetin and kaempferol, and a small amount of volatile oil containing farnesene, germacrene-D, elemene and other terpenes are also present.

Use and indications

Gotu kola is widely used, mainly for inflammatory dermatological disorders and to aid the healing of ulcers and wounds. It is applied externally and taken internally for venous insufficiency and as an immunomodulator and antioxidant, and for many other conditions including memory enhancement, circulatory disorders and anxiety. A number of pharmacological and clinical studies support some of these activities.

Pharmacokinetics

No relevant pharmacokinetic data found. For information on the pharmacokinetics of the individual flavonoids present in gotu kola, see under flavonoids.

Interactions overview

No interactions with gotu kola found. For information on the interactions of the individual flavonoids present in gotu kola, see under flavonoids.