Herb-Drug Interactions: Ground ivy

2011

Glechoma hederacea L. (Lamiaceae)

Synonym(s) and related species

Ale-hoof, Gundelrebe, Gundermann. Nepeta glechoma Benth., Nepeta hederacea (L.) Trevis.

Constituents

Ground ivy contains flavonoids including isoquercitrin, luteolin diglucoside and rutin, and other polyphenohc compounds such as glycosides of icariol, cistanoside E and rosmarinic acid. Other compounds present include beta-sitosterol, the triterpenes oleanolic acid, and alpha- and beta-ursolic acids, and a volatile oil containing the monoterpenes p-cymene, linalool, limonene and terpineol, among others. The sesquiterpene glechomafuran and the diterpene marrubiin are also present. Two alkaloids, hederacine A and B, which may have cytotoxic activity, have been found in very small amounts in the plant.

Use and indications

Ground ivy is used as a mild expectorant for chronic bronchial catarrh. It is also said to be astringent, and therefore used for wound healing, haemorrhoids, gastritis and diarrhoea.

Pharmacokinetics

No relevant pharmacokinetic data found. For information on the pharmacokinetics of individual flavonoids present in ground ivy, see under flavonoids.

Interactions overview

No interactions with ground ivy found. For information on the interactions of individual flavonoids present in ground ivy, see under flavonoids.