Herb-Drug Interactions: Skullcap

Scutellaria lateriflora L. (Lamiaceae)

Synonym(s) and related species

Helmet flower, Hoodwort, Quaker bonnet, Scullcap, Scutellaria.


The major active components of skullcap are the flavonoids scutellarin, scutellarein, baicalein, baicalin (the glucuronide of baicalein), dihydrobaicalin, apigenin, luteolin and other methoxyflavones. The iridoid catalpol, and gamma-amino-benzoic acid (GABA) have also been found and there is a small amount of essential oil present composed of monoterpenes and sesquiterpenes.

Use and indications

Skullcap has been used traditionally as a sedative and to treat nervous disorders. Previous reports about its possible toxicity have been found to be because of contamination with Teucrium species; skullcap itself is now considered to be safe to use.


No relevant pharmacokinetic data found for skullcap, but see flavonoids, for information on individual flavonoids present in the herb.

Interactions overview

No interactions with skullcap found, but for information on the interactions of individual flavonoids present in skullcap, see under flavonoids.