Milk Thistle: Medical Uses
Milk thistle improves liver function tests and helps to counteract mushroom (Amanita phalloides) poisoning if taken within 24 hours after ingestion of the mushroom. It can also be used for chemical-induced liver damage, cirrhosis, and viral hepatitis.
Milk thistle has been used traditionally for liver complaints.
A member of the aster family, milk thistle is native to southern and western Europe and some parts of the U.S.
• Fruits, known as achenes ()
Major Chemical Compounds
Milk Thistle: Clinical Uses
Milk thistle improves liver function tests and reverses mushroom (Amanita phalloides) poisoning if given within 24 hours after ingestion of the mushroom. It can also be used for chemical-induced liver damage, cirrhosis, and viral hepatitis. Silibinin may be useful in prostate cancer. It is approved by the German Commission E for dyspepsia, liver damage, and liver disease.
Mechanism of Action
This herb has antioxidant, hepatoprotective, and hepatorestorative properties. It also increases the gluthione content of liver, inhibits leukotrienes, and stimulates protein synthesis. Silibinin, an antioxidant in milk thistle, has been shown to inhibit prostate cancer cells, although the mechanism of action is still unknown.
Milk Thistle: Dosage
Standardized capsules or tablets: 420 mg divided into two to three doses a day. Results are usually seen after 6 to 8 weeks and should be verified by liver function tests. After 6 to 8 weeks, dosage may be reduced to 280 mg daily.
The patient may develop loose stools at high doses.
• Monitor blood glucose levels in diabetic patients. Standard anti-hyperglycemic medications may need to be reduced..
Monitor blood glucose levels in patients taking diabetic medications.
Pregnancy and Breast-Feeding
There are no restrictions. However, use cautiously in pregnant patients because the herb has a laxative effect.
Summary of Studies
Palasciano et al. (1995). Fifteen subjects receiving butyrophenones and phenothiazines were also given 400 mg b.i.d. of concentrated extracts from the fruits of milk thistle. Results: milk thistle protected the liver from the adverse effects of these drugs.
Milk Thistle: Warnings
• Milk thistle may cause loose stools at high doses.
• Avoid use of this herb if you are pregnant or breast-feeding.