- 0.1 Common Name
- 0.2 Other Names
- 0.3 Botanical Name / Family
- 0.4 Plant Parts Used
- 0.5 Historical Note
- 0.6 Chemical Components
- 1 Myrrh: Main Actions
- 2 Myrrh: Other Actions
Botanical Name / Family
Commiphora molmol (family Burseraceae)
Plant Parts Used
Gum resin, stem, leaves
The resin that seeps out of the bark of the Commiphora plant has been considered an important medicinal product in the Middle East, China and India since biblical times. Because of its antimicrobial activity, myrrh has historically been used, alone and in combination with other herbs, to treat infections and inflammations of the oral cavity, in purification rituals, to embalm bodies, dress infected wounds and as a treatment for leprosy.
Myrrh contains three main components: gum resin 30-60%; alcohol-soluble resins 20-40%; volatile oils (2-10%).
Guggul is the oleo-gum-resin exudate from Commiphora mukul, which is also used therapeutically and has been scientifically investigated. Resins are sticky, water-insoluble substances that are secreted where a plant is damaged by incision or natural causes. The viscous substance hardens shortly after secretion, but may be returned to a liquid state with heating. Resins tend to be soluble in alcohol. Guggulipid is extracted from guggul and contains plant sterols (guggulsterones E and Z) which are thought to be its main pharmacologically active constituents.
Myrrh: Main Actions
Antifungal and antibacterial activity has been observed in vitro against standard pathogenic strains of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans. The oleo-gum-resin of C. mukul was shown to be comparable to kanamycin against both Gram (+) and Gram (-) bacteria in vitro.
Several mechanisms of action are considered responsible for this effect. The guggulsterones act as antagonists of the bile-acid receptor and of the farsenoid X receptor, which are involved in bile acid regulation and cholesterol metabolism. Crude guggul contains ion-exchange resins that may remove bile from the intrahepatic circulation.
According to one review, eleven clinical studies have generally demonstrated that guggulipid from C. mukul significantly reduces triglyceride and total cholesterol levels; however, results from a recent double-blind randomised study were negative.
Myrrhanol A, a triterpene isolated from C. mukul gum resin, produces potent anti-inflammatory activity, as observed in an animal model of inflammation. In this study, anti-inflammatory activity was more marked than that of hydrocortisone. An animal model of RA confirmed significant anti-inflammatory effects with oral administration, also resulting in decreased joint swelling. A small, uncontrolled trial of C. mukul for patients with osteoarthritis (n = 30) has shown treatment with 500 mg (3.5% guggulsterones) of the herb, three times daily for 2 months resulted in reduced joint inflammation, swelling and pain. Although this suggests the effects may be clinically significant, further investigation is required.
Several compounds found within myrrh exert local anaesthetic activity, chiefly by blocking the inward sodium current across membranes.
Myrrh: Other Actions
One major component, T-cadinol, and several minor components possess smooth muscle-relaxing properties according to ex vivo tests.
INCREASES GLUCOSE TOLERANCE
An extract of myrrh effectively increased glucose tolerance in both normal and diabetic rats.
LOCAL ASTRINGENT AND ENHANCED WOUND HEALING
Myrrh has astringent activity, promotes tissue granulation and enhances wound healing.