There have only been two documented adverse reactions. In a 74-year-old diabetic patient with hypertension, and in a 67-year-old patient with endocarditis undergoing tooth extraction, L. rhamnosus preparations caused adverse reaction. The causality was not established and details are scant.
No adverse drug interactions have been reported.
Concomitant administration of probiotics (lactobacilli and Saccharomyces boulardii) reduces gastrointestinal and genitourinary side effects according to clinical studies — combination can be safely used together and a beneficial interaction is likely.
Contraindications and Precautions
Specific strains of probiotics are appropriated for different disorders. Certain strains are suitable for children.
Likely to be safe in pregnancy; however, use of concentrated forms should be supervised by a healthcare professional.