Sage is likely to be safe when taken in amounts typically found in foods, although sage oil contains thujone, which may be toxic in large doses. In large amounts, the camphor and thujone content of sage oil have been shown to have convulsant properties in rats and when taken internally in large amounts, sage may cause restlessness and seizures in humans. Sage tea has also been reported to cause cheilitis and stomatitis, dry mouth and local irritation.
One, double-blind randomised trial found that it was well tolerated and produced fewer side-effects than placebo. Occasional allergic reactions with topical use have been reported.
IRON, CALCIUM, MAGNESIUM
Due to the tannin content, sage may reduce the absorption of these minerals — separate doses by 2-3 hours.
Contraindications and Precautions
Sage oil can irritate the skin when used topically. Internal use of the essential oil should be closely monitored.