Syringa vulgaris L. (Common Lilac)

Syringa vulgaris L., or common lilac is a horticulturally important member of the Oleaceae, a family in which other economically significant genera (Olea, Fraxinus, Jasminum, Forsythia) also occur. Thirty species of Syringa are found distributed across the temperate and south temperate zones of Europe and Asia, while the common lilac has been introduced even more widely as an ornamental. A woody shrub (or small tree) in habit, lilac is typical of the Oleaceae in having opposite leaves, a calyx of four fused sepals and a corolla of four united petals. The highly scented flowers occur in thyrses, each branch bearing a terminal flower. The high demand for common lilac and lilac hybrids in the woody ornamental trade has led to several studies of in vitro propagation of this and related species. New shoot formation could be induced from explants of actively growing shoot tips on MS medium supplemented with 0.1 mg/1 6-benzylaminopurine (BA) and 0.1-0.5 mg/1 indoleacetic acid. These were multiplied on MS medium containing high (7.5 mg/1) levels of BA and low (0.1 mg/1) levels of auxin (NAA). Low cytokinin levels led to callus formation, from which regeneration has yet to be reported in lilac. Successful in vitro multiplication Read more […]

Toxicology and Clinical Applications of Black Pepper

Toxicology of Black Pepper There are no data available on the acute or chronic toxicologic aspects of pepper and/ or its constituents. Pepper constituents are not used therapeutically in the allopathic system. Pepper has been in use since very early times as a spice and food additive. No health hazard or untoward action may arise in the concentrations used. The total contents of piperine and associated phenolic amides are of the order of 7–9 per cent w/w and that of the volatile oil are 2–4 per cent. At this level the actual doses of the different constituents available from the quantity of pepper powder, oleoresin or extractive used, will be very little to elicit any toxic reactions. Moreover, the pungent taste of piperine and flavour of the volatile oil constituents will themselves serve as a limiting factor for the intake of high doses. No acceptable daily intake (ADI) has been prescribed by the Joint FAO/WHO Experts Committee on Food Additives for piperine and/or the volatile principles. The major untoward action of pepper is the gastric mucosal injury at a dose of 1.5 g/kg food. There are a few reports about the carcinogenic potential of piperine. It enhances the DNA adduct formation, and extract of pepper Read more […]

Pharmacology of Black Pepper

Many spices used in food seasoning have broad spectrum of antimicrobial activity. Their antioxidant activity against lipid peroxidation enhances the keeping quality of food. Apart from the use as a popular spice and flavouring substance, black pepper as drug in the Indian and Chinese systems of medicine is well documented. In the Ayurvedic descriptions, pepper is described as katu (pungent), tikta (bitter), usbnaveerya (potency, leading to storing up of energy, easy digestion, diaphoresis, thirst and fatigue), to subdue vatta (all the biological phenomena controlled by CNS and autonomic nervous system) and kapha (implies the function of heat regulation, and also formation of various preservative fluids like mucus, synovia etc. The main functions of kapha is to provide co-ordination of the body system and regularization of all biological activities). Pepper is described as a drug which increases digestive power, improves appetite, cures cold, cough, dyspnoea, diseases of the throat, intermittent fever, colic, dysentery, worms and piles; also useful in tooth ache, pain in liver and muscle, inflammation, leucoderma and epileptic fits. Black pepper is called maricha or marica in Sanskrit, indicating its property to dispel Read more […]

Aloe vera in wound healing: Gel components

Saccharides Mono- and polysaccharides form about 25% of the solid fraction of the aloe gel. Mannose and glucose are the most significant monosaccharides found in the gel. These sugars most commonly serve as fuels and building blocks. For example, mannose-6-phosphate is required to initiate glycoprotien and glycolipid synthesis in the endoplasmic reticulum of all nucleated cells. Optimal nutrition is required for the growth, regulation, reproduction, defense, regeneration and repair during wound healing. In addition, saccharides such as mannose are essential in the golgi apparatus of all cells to complete synthesis of all structural and functional molecules. Lastly, the mannose-6-phosphate of Aloe vera has been shown to activate the insulin-like growth factor receptor of the fibroblast, stimulating it to increase collagen and proteoglycan synthesis. This activity has been shown to increase wound tensile strength. The polysaccharide component of aloe gel is primarily glucommannans that are comprised of glucose and mannose (β1→ 4 linked acetylated mannan). These polysaccharides, unlike other sugars, are absorbed complete and appear in the bloodstream undigested. Here, they have many activities. It has been very Read more […]

Stephania

Importance and Distribution of the Genus The genus Stephania (Menispermaceae) comprises approximately 50 species distributed from Africa through Asia to Australia. The importance of the genus in traditional medicine in Asia and Africa is well documented. The underground tubers of the vines are generally characterized by powerful pharmacological effects. Stephania abyssinica is a creeper indigenous to southern and eastern Africa. The leaves of this plant are used as a purgative and emetic, whereas the roots are employed in the treatment of roundworm, menorrhagia and boils. Stephania bancroftii is used by the aboriginal communities of Australia both as a treatment for diarrhea and as a fish poison. Stephania cepharantha (), a perennial plant native to mainland China known by the vernacular name “bei-yan-zi”, is commonly used as a folk medicinal herb. Decoctions from the tuber of Stephania cepharantha are traditionally used in China to treat a number of diseases including parotiditis, gastric ulcer, leukopenia, alopecia areata and alopecia androgenetica. The major components of this crude drug, known as Cepharanthin preparations, are the bisbenzylisoquinoline (BBI) alkaloids cepharanthine, isotetrandrine and cycleanine. Stephania Read more […]

Malva sp. (Mallow)

Distribution and Importance of the Plant Although about 1000 species are designated with the common name of mallow, approximately 30 species belonging to the genus Malva (of the Malvaceae family) are known for their medicinal value, mostly in a traditional sense. The common (blue or high) mallow (Malva sylvestris L.) is a biennial to short-lived perennial with prostrate to semi-erect stems (10-80 cm long) and long-stalked rounded leaves with a heart-shaped base and five to seven broad shallow-toothed lobes. The leaves of M. sylvestris var. incanescens Gris are hairy. The flowers (appearing from May to September) are pale lilac to bright mauve-purple and the seeds are flat button-like nutlets. The plant is found naturally in marginal or waste lands, hedgerows and roadsides and is approximately 1 m high, with stalked, roundish, five- to seven-lobed leaves. Plant parts abound with a mild mucilage. Malva aegyptia (Egyptian mallow) is an annual species, endemic in the Mediterranean countries, 20-50 cm high with purple-blue flowers. Malva cretica (Crecian mallow) is another Mediterranean species, which is an annual, 10-30 cm high with rose-coloured leaves. Malva ambigua Guss (M. sylvestris var. ambigua) is a Read more […]

Artemisia Absinthium L.

Artemisia absinthium L. is a member of the family Compositae (Asteraceae) and is known by the common names wormwood (UK), absinthe (France) and wermut (Germany). The name Artemisia is derived from the Goddess Artemis, the Greek name for Diana, who is said to have discovered the plant’s virtues, while absinthium comes from the Greek word apinthion meaning “undrinkable”, reflecting the very bitter nature of the plant. The plant is also known by a number of synonyms which include: Absinthium, Wermutkraut, Absinthii Herba, Assenzio, Losna, Pelin, Armoise, Ajenjo and Alsem. The herb is native to warm Mediterranean countries, usually found growing in dry waste places such as roadsides, preferring a nitrogen-rich stoney and hence loose soil. It is also native to the British Isles and is fairly widespread. Wormwood has been naturalised in northeastern North America, North and West Asia and Africa. Brief Botanical Description The stem of this shrubby perennial herb is multibranched and firm, almost woody at the base, and grows up to 130 cm in height. The root stock produces many shoots which are covered in fine silky hairs, as are the leaves. The leaves themselves are silvery grey, 8 cm long by 3 cm broad, abundantly pinnate Read more […]

The Therapeutic Potential For Cannabis

«Cannabis Use and Abuse by Man: An Historical Perspective» of this site provides a fascinating, historical account of the use of cannabis across many cultures and centuries. Suffice it to say here that any natural substance with over 5000 years of medical history will have attached to it a heritage of hearsay and legend through which one must sift to identify areas of true therapeutic potential for us in the late twentieth century and beyond. A summary of conditions for which cannabis has been used, ranging through various shades of rationality, appears in Table Medicinal and quasi-medicinal uses for cannabis and its derivatives: Indications for which only anecdote or reports of traditional use exist: aphrodisiac muscular spasm in rabies / tetanus Huntingdon’s chorea jaundice toothache earache tumour growth cough hysteria insanity menstrual cramps rheumatism movement disorders gut spasm pyrexia inflammed tonsils migraine headache increasing uterine  contractions in childbirth urinary retention/ bladder spasm parasite infection fatigue allergy fever herpetic pain hypertension joint inflammation diarrhoea malaria forgetfulness Indications Read more […]

Specific Medicinal Uses of Cannabis

The historical and contemporary, medicinal uses of cannabis have been reviewed on several occasions. Perhaps the earliest published report to contain at least some objectivity on the subject was that of O’Shaughnessy (1842), an Irish surgeon, working in India, who described the analgesic, anticonvulsant and muscle relaxant properties of the drug. This report triggered the appearance of over 100 publications on the medicinal use of cannabis in American and European medical journals over the next 60 years. One such use was to treat nausea and vomiting; but it was not until the advent of potent cancer chemotherapeutic drugs that the antiemetic properties of cannabis became more widely investigated and then employed. One can argue that the available clinical evidence of efficacy is stronger here than for any other application and that proponents of its use are most likely to be successful in arguing that cannabis should be re-scheduled (to permit its use as a medicine) because it has a “currently accepted medical use”. Specific Medicinal Uses of Cannabis: Use as an Antiemetic Specific Medicinal Uses of Cannabis: Glaucoma Specific Medicinal Uses of Cannabis: Multiple Sclerosis Spastic Conditions A discussion Read more […]

Specific Medicinal Uses of Cannabis: Multiple Sclerosis

Like so many other applications, there are numerous anecdotal reports from both patients and their carers who say that cannabis has proffered relief from a range of symptoms associated with MS, including tremor, spasticity and muscle pain. Evidence for the efficacy of cannabis in the relief of spasticity other than that found in MS is discussed in Spastic Conditions. Cannabis Meinck et al. () describe a case where the benefits of smoking cannabis reported by the patient — improvement in muscle tone, reflexes, spasticity, tremor and walking ability — were quantifiable in the laboratory and deteriorated on withdrawal. In a double-blind, placebo controlled trial of cannabis in 10 ambulant patients with MS, the drug impaired posture and balance although several patients reported an improvement in subjective feelings of well-being; a formal psychological assessment was not carried out. Anecdotal evidence gathered from the testimonials of MS sufferers indicates that a considerable proportion obtain at least partial relief from night-time spasticity, and reduced muscle pain, tremor and depression. THC Petro and Ellenburger reported a placebo-controlled trial of oral THC in 9, cannabis-naive patients with MS. Each Read more […]