A Clinical Investigation of Perilla Extract Cream for Atopic Dermatitis

Atopic dermatitis is one kind of allergic disease. Allergies are very closely associated with an immune response. When the human body is invaded by a foreign substance (antigen), antibodies or sensitised lymphocytes will be produced as a result of the response of the immune system. Later when the same antigen invades the body again, it will soon be eliminated or become harmless to the body. This is an immune response which is an indispensable function to prevent infection and tumours. However, sometimes the immune reaction between antigen and antibodies or sensitised lymphocytes can cause harm to the body itself. This kind of immune reaction in which antigen comes from outside the body causes allergic disease, whereas antigen which comes from the body itself causes auto-immune disease. According to the statistical investigation in 1992 by the Ministry of Welfare of Japan, 34% of the Japanese population suffer from some kind of allergy, and most of them are children between the age of 0 to 4. There is the tendency for allergic symptoms to appeal- as atopic dermatitis in childhood and to become asthma or rhinitis as they mature. The word atopy is derived from Greek () and means odd and thus atopic dermatitis is Read more […]

Prescriptions For Skin Diseases

The following prescriptions are suggested as a starting point. Herb selection depends on pathophysiology, the patient, the herbs most suited to the individual, and the actions of the herbs. General strategies Consider regulating or enhancing specific body systems, organs, or tissues, and using alteratives to correct imbalances. The gut-skin connection is a central consideration. While the action of alteratives is unclear, they are invaluable in the treatment of chronic allergic skin disease. Optimize nutrition, and improve vitality by using tonics and adaptogens. Concurrent conventional therapy may be required initially, and doses may need to be reduced after 4 to 6 weeks. Continue herbal therapy for a minimum of 3 months. Atopy and skin allergies Reduce exposure to known allergens. Consider an elimination diet, as well as herbs that modulate immunity (those that down regulate TH2 cells). Use herbs to reduce allergic pruritis and those with antiinflammatory action. Also consider herbs that inhibit mast cell release of histamine. For allergic dermatitis with either dry or moist skin lesions, give: Burdock: Depurative, mildly laxative, nutritive; 1 part. Red clover: Alterative; 1 part. Cleavers: Diuretic, Read more […]

Quercetin: Background. Actions

Background and Relevant Pharmacokinetics Quercetin is a flavonol belonging to a group of polyphenolic substances known as flavonoids or bioflavonoids. The first flavonoids were identified in 1936 by Albert Szent-Györgyi, who was awarded the Nobel Prize for his discovery of vitamin C. Studies on the absorption, bioavailability, and metabolism of quercetin after oral intake in humans have produced contradictory results. The nature of quercetin metabolites in plasma is currently unclear and requires further elucidation, which may in part explain these inconsistencies. There appears to be marked individual variation in absorption rates ranging from 0% to over 50%. Factors that may improve bioavailability include: gender (especially females taking oral contraceptives), gastrointestinal flora, and concurrent intake of bromelain and papain. Absorption from onions is three times that of apples and twice that of black tea. The main determinant for the absorption of quercetin conjugates is the nature of the sugar moiety. Glucose-bound glycosides (quercertin glucosides) are effectively absorbed from the small intestine because the cells possess glucoside-hydrolysing activity and their glucose transport system is capable Read more […]