Healing Powers of Aloes: Pharmacology and Therapeutic Applications

Constipation Aloe latex possesses laxative properties and has been used traditionally to treat constipation. The old practice of using aloe as a laxative drug is based on its content of anthraquinones like barbaloin, which is metabolised to the laxative aloe-emodin, isobarbaloin and chrysophanic acid. The term ‘aloe’ (or ‘aloin’) refers to a crystalline, concentrated form of the dried aloe latex. In addition, aloe latex contains large amounts of a resinous material. Following oral administration the stomach is quickly reached and the time required for passage into the intestine is determined by stomach content and gastric emptying rate. Glycosides are probably chemically stable in the stomach (pH 1–3) and the sugar moiety prevents their absorption into the upper part of the gastrointestinal tract and subsequent detoxification in the liver, which protects them from breakdown in the intestine before they reach their site of action in the colon and rectum. Once they have reached the large intestine the glycosides behave like pro-drugs, liberating the aglycones (aloe-emodin, rhein-emodin, chyrosophanol, etc.) that act as the laxatives. The metabolism takes place in the colon, where bacterial glycosidases are Read more […]