Cervical Dysplasia: Discussion Of Botanicals

Blood Root The blood-red color of the sap from the roots of blood root led to its traditional use as a blood purifier. It was used as an emmenagogue, in the treatment of respiratory conditions, as a strong emetic, and for the treatment of fungal infections and ulcers. By the eighteenth century, blood root was used topically to treat indolent chancres and tumors as an ingredient in the popular “black salve,” an escharotic treatment that was used topically for the treatment of tumors. Extracts of sanguinarine, an alkaloid from the herb, have been shown to possess anti-inflammatory, antimicrobial, antioxidant, antiviral, antiproliferative, and apoptotic activities, and are under active research for the treatment of cancer. Sanguinarine, an alkaloid compound fund in blood root, is a potent inhibitor of NF-kappa B activation.’ Sanguinarine is an ingredient in dental hygiene products, for example, toothpaste, used for its antiplaque activity and in the treatment of gingivitis. There is controversy over the safety of its use in dental products, with contradictory research over whether it may cause malignant cell change and lead to the development of leukoplakia. Most studies have concluded that the extract is safe for dental Read more […]

Iron: Significant Interactions

Iron interacts with a variety of foods, herbs and drugs through several different mechanisms. Most commonly, the formation of insoluble complexes occurs whereby both iron and drug absorption is hindered. Separation of doses by several hours will often reduce the severity of this type of interaction. Additionally, substances that alter gastric pH have the theoretical ability to reduce iron absorption. A summary of interactions has been presented in table form for easy reference. Drug / therapeutic substance Mechanism Possible outcome Action required ACE inhibitors Reduced absorption of ACE inhibitors. A small clinical trial found that concomitant iron administration reduced area-under-the-curve plasma levels of unconjugated captopril by 37% Reduced drug effect Separate doses by at least 2 hours Antacids and products containing aluminium, calcium or magnesium Reduces iron absorption Reduced effect of iron Separate doses by at least 2 hours Ascorbic acid Increases iron absorption Increased effects of iron Beneficial interaction possible — caution in haemochromatosis Cholestyramineand colestipol In vitro investigations have shown that cholestyramineand colestipol Read more […]