Taxol (Paclitaxel) and Cancer Chemotherapy

Taxol is an antineoplastic agent. This compound, first isolated from the bark of the Western yew tree in 1971, exhibits unique pharmacological actions as an inhibitor of mitosis, differing from the vinca alkaloids and colchicine derivatives in that it promotes rather than inhibits microtubule formation. Following its introduction into clinical trial, the drug was approved for treatment of cisplatin-refractory ovarian cancer in 1992 and has promising activity against cancers of the breast, lung, esophagus, and head and neck. Malignant neoplastic diseases may be treated by various approaches: surgery, radiation therapy, immunotherapy, or chemotherapy, or a combination of these. The extent of a malignant disease (staging) should be ascertained in order to plan an effective therapeutic intervention. Plants have antineoplastic activities. A significant portion of the product derived from plants serve either as protective agents against various pathogens (e.g., insects, fungi, or bacteria) or growth regulatory molecules (e.g., hormonelike substances that stimulate or inhibit cell division and morphogenesis). Chemical Groups Of Natural Products With Anticancer Properties Cancer Chemotherapy Before discussing the specific Read more […]

Herbs For Gastrointestinal Disorders

In herbal medicine, there is a recognized fundamental linkage between the gut and systemic health in conditions as widely ranging as asthma, atopy, autoimmune disease, and even arthritis. This is important, considering that the gut plays a significant role in immune function. Herbalists emphasize the health of the digestive system, bowel movements, and any symptoms related to gut function — even mild digestive disturbances such as burping, mild constipation, inconsistent stools, or excessive flatulence are always considered significant, even if not the reason for presentation for consultation. The herbs outlined below are useful in gastrointestinal health and disease management and are supported by traditional use or research. The lists are by no means complete, and there are differences in the potency of the actions of the individual herbs. However, by knowing the particulars of the patient, an herb might be chosen for its breadth of action when more than 1 system is involved or for a particularly strong action that is needed. Sometimes only a gentle stimulation, triggering an appropriate reflex response or dampening a response, may be all that’s needed to reach equilibrium again. The beauty and art of herbal Read more […]

ANTIEMETICS

ANTIEMETICS are used to prevent vomiting. They are thus related to antinauseant drugs which are used to reduce or prevent the feeling of nausea that very often precedes the physical process of vomiting (emesis). Commonly, the terms are used synonymously, though it is usually an antinauseant action that is being sought. The type of antinauseant drugs used, and the likelihood of success, depends on the mechanism and origin of the nauseous sensation, and there are a number of ways it can be triggered. Motion sickness (travel sickness) can often be prevented by taking antinauseant drugs before travelling, e.g. the antihistamines meclozine and dimenhydrinate, and the anticholinergic hyoscine. Probably all these drugs act as central MUSCARINIC CHOLINOCEPTOR ANTAGONISTS. Similar drugs may be used to treat nausea and some other symptoms of labyrinthine disease (where the vestibular balance mechanisms of the inner ear are disturbed, e.g. in Meniere’s disease), though other antinauseant drugs may also be necessary, e.g. cinnarizine or phenothiazine derivatives such as chlorpromazine and prochlorperazine. Steroids, such as dexamethasone and methylprednisolone, are effective antiemetics that work by an undefined mechanism. In view Read more […]