The Therapeutic Potential For Cannabis

«Cannabis Use and Abuse by Man: An Historical Perspective» of this site provides a fascinating, historical account of the use of cannabis across many cultures and centuries. Suffice it to say here that any natural substance with over 5000 years of medical history will have attached to it a heritage of hearsay and legend through which one must sift to identify areas of true therapeutic potential for us in the late twentieth century and beyond. A summary of conditions for which cannabis has been used, ranging through various shades of rationality, appears in Table Medicinal and quasi-medicinal uses for cannabis and its derivatives: Indications for which only anecdote or reports of traditional use exist: aphrodisiac muscular spasm in rabies / tetanus Huntingdon’s chorea jaundice toothache earache tumour growth cough hysteria insanity menstrual cramps rheumatism movement disorders gut spasm pyrexia inflammed tonsils migraine headache increasing uterine  contractions in childbirth urinary retention/ bladder spasm parasite infection fatigue allergy fever herpetic pain hypertension joint inflammation diarrhoea malaria forgetfulness Indications Read more […]

Specific Medicinal Uses of Cannabis: Effects on Anxiety and Insomnia

Cannabis smoking produces a relaxant effect which most users value and it has been suggested that the beneficial effects of cannabis and THC observed in neurological disorders such as motor tics, dystonias and Huntingdon’s chorea are due to sedative and anxiolytic actions. In addition, sedation is by far the most common side effect of cannabis, and in particular THC, observed in clinical trials against a range of disorders. This has lead to the suggestion that cannabis and some cannabinoids may be useful in disorders accompanied by anxiety and/or insomnia. Cannabis Sethi et al. () noted a reduction of anxiety in 50 chronic cannabis users compared to controls, in terms of scores on the Taylor Manifest Anxiety Scale. Oral preparations of cannabis have a sedative or tranquillising effect in man, accompanied by diminished anxiety at doses much lower than those producing psychoactivity. However, anxiety and panic, possibly due to depersonalisation, intoxication and loss of control, can also feature as side effects. These symptoms have been observed after smoking or oral ingestion of cannabis, but particularly after intravenous administration of aqueous extracts. This may be due to the rapid onset of altered mental state Read more […]

Globe artichoke: Uses. Dosage

Clinical Use HYPERUPIDAEMIA Data are available from both controlled and uncontrolled studies that have investigated the effects of artichoke leaf extract in hyperlipidemia. Most studies use Hepar SL forte® orValverde Artischoke bei Verdauungsbeschwerden (artichoke dry extract) containing 450 g of herbal extract as a coated tablet. Data from five uncontrolled studies and case series suggests that artichoke leaf extract and cynarin have lipid-lowering effects and a possible role as adjunctive therapy in hyperlipidaemia. A Cochrane systematic review that analysed the results of two controlled studies concluded that artichoke leaf extract appears to have a modest positive effect on the levels of total cholesterol and LDL; however, there is insufficient evidence to recommend it as a treatment option for hypercholesterolaemia and trials with larger samples sizes are still required. One of the studies was a randomised, placebo-controlled, double-blind, multicentre trial involving 143 subjects with total cholesterol levels >7.3 mmol/L (>280 g/dL). A dose of 1800 mg artichoke leaf extract was administered daily for 6 weeks. Active treatment resulted in 18.5% decrease in serum cholesterol compared with 8.6% Read more […]

Hops: Interactions. Practice Points. FAQ

Adverse Reactions Drowsiness is theoretically possible at excessive doses. Contact with the herb or oil has resulted in reports of systemic urticaria, allergic dermatitis, respiratory allergy and anaphylaxis. Significant Interactions Interactions reported here are theoretical and have yet to be tested clinically for significance. PHARMACEUTICAL SEDATIVES Additive effects are theoretically possible — observe the patient (this interaction may be beneficial). DRUGS METABOLISED CHIEFLY WITH CYP2B OR CYP3A Altered drug effect — CYP induction and inhibition has been demonstrated. However, it is unknown if these effects are clinically significant — observe the patient for signs of altered drug effectiveness. ANTI-OESTROGENIC DRUGS Hops may alter the efficacy of these medicines; use with caution in patients taking anti-oestrogenic drugs. Contraindications and Precautions According to one source, hops should be used with caution in depression. Due to the herb’s oestrogenic activity, disruption to the menstrual cycle is considered possible. Use is contraindicated in patients with oestrogen-dependent tumours. Pregnancy Use Caution in pregnancy because of possible hormonal effects. Practice Points / Patient Read more […]