The Therapeutic Potential For Cannabis

┬źCannabis Use and Abuse by Man: An Historical Perspective┬╗ of this site provides a fascinating, historical account of the use of cannabis across many cultures and centuries. Suffice it to say here that any natural substance with over 5000 years of medical history will have attached to it a heritage of hearsay and legend through which one must sift to identify areas of true therapeutic potential for us in the late twentieth century and beyond. A summary of conditions for which cannabis has been used, ranging through various shades of rationality, appears in Table Medicinal and quasi-medicinal uses for cannabis and its derivatives: Indications for which only anecdote or reports of traditional use exist: aphrodisiac muscular spasm in rabies / tetanus Huntingdon’s chorea jaundice toothache earache tumour growth cough hysteria insanity menstrual cramps rheumatism movement disorders gut spasm pyrexia inflammed tonsils migraine headache increasing uterine  contractions in childbirth urinary retention/ bladder spasm parasite infection fatigue allergy fever herpetic pain hypertension joint inflammation diarrhoea malaria forgetfulness Indications Read more […]

CORTICOTROPHIN-RELEASING FACTOR RECEPTOR ANTAGONISTS

CORTICOTROPHIN-RELEASING FACTOR RECEPTOR ANTAGONISTS inhibit the actions of agents related to corticotrophin-releasing factor (CRF). Two subtypes of receptor, CRF, and CRF2, have recently been identified and cloned, and there is interest in these as therapeutic targets. See CORTICOTROPHIN-RELEASING FACTOR RECEPTOR AGONISTS. Some peptide antagonists that have some affinity for both CRF, and CRF2 receptors have been developed by making modifications of the CRF sequence, and these include; a-helicalCRE9-41,DPhe-CRF12-41 and the peptide astressm. Recently, some related non-peptides that act selectively at CRF, receptors have been developed including CP 154526, NB 127914 and antalarmin. A number of other agents are currently the subject of patent applications. Some possibly clinical applications of CRF receptor ligands are discussed in relation to evidence about the role of CFG; see corticotrophin-releasing factor receptor agonists. It might be hypothesized that corticotrophin-releasing factor antagonists could be used clinically to treat panic and generalized anxiety disorders, and possibly also to treat clinical depression and anorexia. Similarly, there is some evidence suggesting that stroke might be treatable with Read more […]