Withania: Significant Interactions

Controlled studies are not available; therefore, interactions are based on evidence of activity and are largely theoretical and speculative.

BARBITURATES

Additive effects are theoretically possible leading to increased. Observe patients taking withania and barbiturates concurrently — beneficial interaction possible under medical supervision.

BENZODIAZEPINES

Additive effects are theoretically possible. Observe patients taking withania and benzodiazepines concurrently— beneficial interaction possible under professional supervision.

CHEMOTHERAPY

Animal studies suggest a potential role for withania as an adjunctive treatment during chemotherapy for the prevention of drug-induced bone marrow depression. Observe — beneficial interaction possible under professional supervision.

IMMUNOSUPPRESSANTS (INCLUDING CYCLOPHOSPHAMIDE)

The ability to stimulate stem cell proliferation has led to concerns that Withania somnifera could reduce cyclophosphamide-induced toxicity and its usefulness in cancer therapy although preliminary animal studies indicate a potential role as a potent and relatively safe radiosensitiser and chemotherapeutic agent. Theoretically it may also decrease the effectiveness of other immunosuppressant drugs. Caution should be exercised with patients taking immunosuppressants concurrently; however, a beneficial interaction may be possible under professional supervision.

MORPHINE

In animal studies, repeated administration of withania (100 mg/kg) inhibited morphine tolerance and dependence. For this reason it is sometimes used in opiate withdrawal. Beneficial interaction possible under professional supervision.

THYROID MEDICATION (E.G. LEVOTHYROXINE)

Additive effects are theoretically possible as an in vivo study reported that daily administration of withania enhanced serum T4 concentrations — observe patients taking withania and thyroid medications concurrently.