Herb-Drug Interactions: Eclipta

Eclipta alba Hassk (Asteraceae)

Synonym(s) and related species

Trailing eclipta. Eclipta prostrata (L.).

Constituents

Eclipta contains terthienyl derivatives, including alpha-formylterthienyl and a number of esterified 5-hydroxyterthienyl derivatives. The leaves and stem contain the flavonoids apigenin and luteolin, and the isoflavone orobol; wedelolactone and desmethylwedelolactone, as well as their glucosides, are present throughout the herb. Oleanane-type triterpenoids known as the ecliptasaponins, eclalbatin and the eclalbasaponins (based on echinocystic acid), and several steroidal alkaloids based on verazine and ecliptalbine, are also found in eclipta.

Use and indications

Eclipta is traditionally used for blood-related diseases, including liver diseases such as hepatitis and jaundice. Pharmacological studies support these uses to some extent, but clinical data are lacking. It has also been used for alopecia, as an antiseptic and as an analgesic; its analgesic effects have been attributed to the alkaloid content.

Pharmacokinetics

No relevant pharmacokinetic data found. For information on the pharmacokinetics of individual flavonoids and isoflavones present in eclipta, see under flavonoids and isoflavones, respectively.

Interactions overview

No interactions with eclipta found. For information on the interactions of individual flavonoids and isoflavones present in eclipta, see under flavonoids and isoflavones, respectively.