Herb-Drug Interactions: Pumpkin

Cucurbita pepo L. (Cucurbitaceae)

Synonym(s) and related species

Cucurbita, Gourd, Melon pumpkin seeds, Squash.

Cucurbita maxima Duchesne and other Cucurbita species.


Pumpkin seeds contain a fixed oil, the predominant fatty acids of which are linoleic, oleic, palmitic and stearic. There is a high sterol content with cholestanol and lathostanol derivatives present, and vitamin E, particularly gamma-tocopherol. The seeds also contain a number of cucurbitacins such as cucurbitin, the type and concentration depending on growth and variety.

Use and indications

Pumpkin seeds are widely used as a foodstuff. Traditionally, they were used to treat tapeworm infection (cucurbitin has anthelmintic effects), but more recently they have begun to be more widely used to treat benign prostatic hyperplasia.


No relevant pharmacokinetic data found.

Interactions overview

No interactions with pumpkin seed found. Note that pumpkin seeds are widely used as a foodstuff.