Emerging Pharmacological Therapies For Erectile Dysfunction

In addition to Sheng Jing and acupuncture, which are old, and gene therapy, which is novel and new, other emerging therapeutics for erectile dysfunction are the following:

• Phosphodiesterase inhibitors (sildenafil, viagra)

• Cyclic AMP activators (vasoactive intestinal polypeptide)

• Alpha-Adrenergic receptor antagonists (phentolamine, yohimbine)

• Dopaminergic receptor agonists (apomorphine)

• Alpha-Melonocyte stimulating hormone

• Potassium channel modulators

• Endothelin antagonists

• Nitric oxide donors

• Drugs topically applied to penis (transdermal or transglandular nitroglycerine, capsaicine, papaverine, or prostaglandin E1)

Viagra (Sildenafil) — In March 1998, the FDA announced that Viagra®, a new drug from Pfizer, Inc., has been approved as treatment for male sexual dysfunction

Cialis (Tadalafil) — Works fast — within 30 min in some patients — and can work up to 36 hours.

Vardenafil (Levitra) — Levitra is an FDA-approval oral prescription medication for the treatment of erectile dysfunction in men.

The Herbal Virility herbs and minerals have been claimed to show specific improvements in the following areas:

Catuaba (bark) — Increases libido, relieves fatigue, aphrodisiac, nerve tonic.

Tribulus (aerial) — Boosts testosterone levels and sperm production, aids in increasing libido and male infertility.

L-Arginine (HCL) — Increases blood flow to the genital area and gives erections that are harder, last longer and can be more frequent.

Asian ginseng (root) — Arousing, stimulating, energy enhancing effect. Increases physical performance and activity.

Orchic substance (bovine) — Extract from bovine testes used to increase testosterone levels.

Maca (tuber) — Aphrodisiac, increases sexual desire, may help to increase sperm count.

Stinging nettle (leaves) – Body tonic, rich nutritional content of vitamins and minerals, helps in recovery and preventing exhaustion.

Orexis ingredients:

Tribulus terrestris — A plant found throughout Australia, Asia, Africa, and North and South America. It contains saponins, polysaccharides, sterols, flavonoids, and fatty acids, many of which are indicated to have general health benefits. Tribulus terrestris is a natural testosterone enhancer, shown in clinical studies to increase testosterone levels by aiding in the production of the luteinizing hormone (LH), a hormone that influences sex drive. Tribulus terrestris has been used to increase fertility and aid impotence.

Epimedium — An important supplement in traditional Chinese medicine and is gaining popularity in Western homeopathy as well. Epimedium is a leafy plant that grows best at higher altitudes. Its leaves contain a variety of healthful flavonoids, polysaccharides, and sterols, as well as an alkaloid called magnaflorine. Its exact mechanism of action is still somewhat a mystery, but it has shown success for many years in boosting sexual desire, aiding erectile function, and fighting fatigue. Clinical practitioners have long used epimedium to treat erectile problems, to improve libido, and to restore sexual vitality.

Yohimbe extract —Yohimbe (Pausinystalia yohimbe) is an evergreen botanical native to Africa containing a substance called yohimbine, together with additional similar compounds called indole alkaloids. Synthesized yohimbine has been used medicinally for many decades. Yohimbe is a traditional male aphrodisiac recognized worldwide for the treatment of impotence. Today, the drug yohimbine is considered an effective treatment for erectile dysfunction. Yohimbine acts similar to Viagra and increases penile blood flow, and may also increase the amount of cGMP, a substance required for the stimulation and maintenance of erections.

• Muira pauma — Muira puama is a native shrub of Brazil. It has long been used to improve libido and increase sexual potency.

Panax ginseng — Ginseng is traditionally used to overcome general weakness and deliver extra energy. It also has demonstrated aphrodisiac powers. Used to combat impotence, infertility, and premature ejaculation, it normalizes blood pressure while rejuvenating and revitalizing the body. It also promotes the growth of nerve tissue. A key ingredient of ginseng is ginsenoside, which alters blood flow to the brain and penis and can build blood and sperm.

Catuaba bark extract — Catuaba has a long history in herbal medicine as an aphrodisiac. The Tupi Indians in Brazil first discovered the qualities of the plant Andover the last centuries.

Damiana (Turnera aphrodisiaca) — Found throughout Mexico, Central America, and the Caribbean, the Latin name of this herb suggests its use as an aphrodisiac.

Orexis is advertised to increase sexual performance immediately and effectively.