AMYLIN RECEPTOR AGONISTS activate receptors of a seven-transmembrane G-protein-coupled receptor super-family, which couple positively to the adenylyl cyclase (G1) pathway recognizing amylin (islet amyloid polypeptide; IAPP; amlintide, islet amyloid polypeptide, islet-associated polypeptide; insuloma polypeptide; diabetes associated peptide; DAP). Amylin is a peptide pancreatic islet hormone, co-stored and secreted with insulin, whose functions include several aspects of regulation of glucose homeostasis. There is an interest in developing stable agonists to treat diabetes and possibly obesity. Some actions of amylin (e.g. vasodilatation) are not due to amylin receptor activation, but rather crosstalk and act as a CALCITONIN GENE-RELATED PEPTIDE RECEPTOR AGONIST or a CALCITONIN RECEPTOR AGONIST.