Probiotics: Interactions. Contraindications and Precautions. Pregnancy Use

Adverse Reactions

There have only been two documented adverse reactions. In a 74-year-old diabetic patient with hypertension, and in a 67-year-old patient with endocarditis undergoing tooth extraction, L. rhamnosus preparations caused adverse reaction. The causality was not established and details are scant.

Significant Interactions

No adverse drug interactions have been reported.


Concomitant administration of probiotics (lactobacilli and Saccharomyces boulardii) reduces gastrointestinal and genitourinary side effects according to clinical studies — combination can be safely used together and a beneficial interaction is likely.

Contraindications and Precautions

Specific strains of probiotics are appropriated for different disorders. Certain strains are suitable for children.

Probiotics are contraindicated in those people who are hypersensitive to any component of the probiotics-containing product.

Pregnancy Use

Likely to be safe in pregnancy; however, use of concentrated forms should be supervised by a healthcare professional.