Herb-Drug Interactions: Red vine leaf

Vitis vinifera L. (Vitaceae)

Synonym(s) and related species

Vitis vinifera is the Grape vine, of which there are many cultivars. Red vine leaf is a cultivar with red leaves.


Red vine leaf contains a range of polyphenolics, mainly flavonoids, proanthocyanins and anthocyanins. The major flavonoids in the extract are quercetin and isoquercitrin. Catechins present include gallocatechin and epigallocatechin and their polymers. The red colour is due to the anthocyanins, which are mainly glucosides of malvidin, but also of delphinidin, cyanidin and pertunidin. Hydroxy-cinnamic acids (e.g. caffeic acid) and resveratrol are also present.

Use and indications

Red vine leaf extract is used both internally and externally to improve blood circulation, particularly in the legs for varicose veins. There is some clinical evidence to support its use in venous insufficiency.


No relevant pharmacokinetic data found. See under flavonoids, for information on the individual flavonoids present in red vine leaf, and see under resveratrol, for the pharmacokinetics of resveratrol.

Interactions overview

No interactions with red vine leaf found. For information on the interactions of flavonoids, see under flavonoids, and for the interactions of resveratrol, see under resveratrol.